If you suffer from gastroesophageal reflux disease (GERD), you’re likely familiar with the discomfort of heartburn and the quick relief that over-the-counter antacids or prescription medications like proton pump inhibitors (PPIs) can provide. While these medications—such as omeprazole and lansoprazole—are effective at reducing stomach acid and alleviating symptoms, they are not without significant risks, especially when used long-term.

The Hidden Dangers of PPIs

PPIs are among the most commonly prescribed medications for GERD. They work by blocking the enzyme in the wall of the stomach that produces acid. While this can provide short-term relief, research has shown that prolonged use of PPIs can lead to a range of serious health issues:

- **Increased Risk of Bone Fractures:** PPIs can interfere with calcium absorption, leading to weaker bones and a higher risk of fractures.  

  **Reference:** Yu, E.W., et al. (2011). Proton Pump Inhibitors and Risk of Fractures: A Meta-analysis of 11 International Studies. *The American Journal of Medicine*, 124(6), 519-526. [https://pubmed.ncbi.nlm.nih.gov/21605729/](https://pubmed.ncbi.nlm.nih.gov/21605729/)

- **Higher Risk of Heart Attack:** Studies have found that long-term PPI use may increase the risk of heart attack.  

  **Reference:** Shah, N.H., et al. (2015). Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. *PLoS ONE*, 10(6): e0124653. [https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124653](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124653)

- **Gastric and Esophageal Cancer:** Chronic suppression of stomach acid can increase the risk of gastric cancer and has been linked to a higher incidence of esophageal adenocarcinoma.  

  **Reference:** Cheung, K.S., et al. (2017). Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study. *Gut*, 67(1), 28-35. [https://gut.bmj.com/content/67/1/28](https://gut.bmj.com/content/67/1/28)

- **Nutrient Deficiencies:** PPIs can reduce the absorption of essential nutrients such as magnesium, vitamin B12, and iron, leading to deficiencies over time.  

  **Reference:** Lam, J.R., et al. (2013). Proton Pump Inhibitor and Histamine 2 Receptor Antagonist Use and Vitamin B12 Deficiency. *JAMA*, 310(22), 2435-2442. [https://jamanetwork.com/journals/jama/fullarticle/1788456](https://jamanetwork.com/journals/jama/fullarticle/1788456)

- **Increased Risk of Infections:** Lower stomach acid can make you more susceptible to gastrointestinal infections, including Clostridium difficile.  

  **Reference:** Janarthanan, S., et al. (2012). Clostridium difficile–Associated Diarrhea and Proton Pump Inhibitor Therapy: A Meta-Analysis. *The American Journal of Gastroenterology*, 107(7), 1001-1010. [https://pubmed.ncbi.nlm.nih.gov/22688849/](https://pubmed.ncbi.nlm.nih.gov/22688849/)

A Holistic Approach: Unani Tibb and Herbal Medicine

At Natural Therapeutics, we believe in treating the underlying causes of disease through a holistic approach. This includes dietary and lifestyle modifications, as well as the use of herbal medicines that have been scientifically validated for their effectiveness in managing GERD.

Proven Herbal Treatments for GERD

1. **Deglycyrrhizinated Licorice (DGL)**

   - **How it works:** DGL helps increase mucus production in the stomach, which protects the lining from acid and promotes healing.

   - **Evidence:** 

     - *Raveendra, K.R., et al. (2012). Efficacy and safety of Glycyrrhiza glabra (DGL) in the management of functional dyspepsia: A randomized, double-blind, placebo-controlled study.* Indian Journal of Pharmacology, 44(5), 660-664. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512355/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512355/)

2. **Marshmallow Root (Althaea officinalis)**

   - **How it works:** Marshmallow root contains mucilage, a gel-like substance that coats and soothes the digestive tract, reducing irritation from acid reflux.

   - **Evidence:** 

     - *Gruenwald, J., et al. (2004). Marshmallow root: Traditional and modern use. HerbalGram, 62, 40-49.* [https://www.herbalgram.org/resources/herbalgram/issues/62/table-of-contents/article2707/](https://www.herbalgram.org/resources/herbalgram/issues/62/table-of-contents/article2707/)

3. **Slippery Elm (Ulmus rubra)**

   - **How it works:** Like marshmallow root, slippery elm is rich in mucilage, which forms a protective barrier in the esophagus and stomach.

   - **Evidence:** 

     - *Al-Achi, A. (2005). A current look at Slippery Elm (Ulmus rubra Muhl.). International Journal of Pharmaceutical Compounding, 9(4), 306-309.* [https://pubmed.ncbi.nlm.nih.gov/23969822/](https://pubmed.ncbi.nlm.nih.gov/23969822/)

4. **Chamomile (Matricaria recutita)**

   - **How it works:** Chamomile has anti-inflammatory and calming properties that can help reduce gastric irritation and promote relaxation of the digestive tract.

   - **Evidence:** 

     - *Srivastava, J.K., et al. (2010). Chamomile: A herbal medicine of the past with a bright future. Molecular Medicine Reports, 3(6), 895-901.* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995283/)

Lifestyle and Dietary Recommendations

Herbal remedies are most effective when combined with lifestyle changes, such as:

- Avoiding trigger foods (spicy, fatty, or acidic foods)

- Eating smaller, more frequent meals

- Not lying down immediately after eating

- Maintaining a healthy weight

- Managing stress

 Conclusion

While PPIs can provide temporary relief from GERD, their long-term use carries significant risks. A holistic approach—focusing on diet, lifestyle, and scientifically proven herbal remedies—can offer effective, sustainable relief without the dangers associated with chronic medication use.

If you’re interested in exploring natural alternatives for GERD management, book a consultation at Natural Therapeutics. Together, we can develop a personalized plan to restore your digestive health and overall well-being.

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**Disclaimer:** This article is for educational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before making changes to your medication or treatment plan.

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